I think it has to do with the load on the engine---I hope this makes sense---and is correct.
4th gear is 1.000:1 ratio, which is why 4th is chosen on the dyno for the majority of tuning. 1st - 3rd ratios > 1.000:1, putting even less load on the engine than 4th gear at the same rpm. 5th and 6th, of course, are overdrive gears. At WOT in an overdrive gear, more load is placed on the engine, requiring more fuel, which produces a more powerful exhaust flow, thus driving the turbo even harder.
Reminds me of how the Ecoboost F-150 guys say, "the turbos really come alive and get on peak boost in a heartbeat when I'm towing the boat". Well, yeah...more load on engine = more exhaust flow = more immediate turbo response + potential for overboost.
I think @
HolyCrapItsFast wrote something similar one time about the effects of "lugging" the engine, i.e. WOT at low rpm in high gear. There's also some discussions about this in the Sticky, "good info for first time turbo car owners" or something like that.
My current tune hits about 19 psi in 1st - 4th and about 21 psi in 5th - 6th. For this reason, I try not to go WOT in 5th or 6th unless I'm already doing +120 mph.